How CBD Patches Work for Pain Relief CBD (cannabidiol) interacts with the endocannabinoid system (ECS) to regulate pain, inflammation, and ov eral l well-being . CBD patches deliver cannabidiol directly into the bloodstream through the skin, providing consistent and long-lasting pain relief without oral consumption. If you're looking for long-term, non-invasive pain relief, CBD patches may be a natural and effective alternative to conventional painkillers. However, consult a doctor before changing your pain management routine.