CBD Capsules for Mood Support : Can They Help with Depression? CBD (cannabidiol) is widely recognized for its potential health benefits , including its role in mood regulation. As interest in natural alternatives for mental well-being grows, many people are turning to CBD capsules as a possible aid for depression. But can they truly help? Let’s explore the science behind CBD and its effects on mood support. How CBD Interacts with Mood Regulation CBD interacts with the endocannabinoid system (ECS), which plays a crucial role in regulating mood, stress response, and emotional balance. Unlike THC, CBD does not cause a high but instead influences neurotransmitters like serotonin and dopamine, which are linked to feelings of happiness and well-being.