Mistakes to Avoid When Taking Berberine Capsules Berberine is a powerful natural compound known for its benefits in supporting blood sugar balance, heart health, weight management, and more. But while it’s highly effective, many people unknowingly make mistakes when taking berberine capsules, reducing its benefits or even causing side effects. Here’s a detailed guide on common mistakes to avoid when using berberine capsules, so you can get the most out of this natural supplement safely and effectively. Taking Too Much at Once Berberine has a short half-life and is best taken in divided doses throughout the day (e.g., 500 mg 2–3 times daily). Taking a large single dose can overwhelm the digestive system, cause side effects like cramping or diarrhea, and reduce effectiveness. Tip: Stick to smaller doses spaced out with meals for better absorption and fewer side effects. Not Taking It with Food Berberine may cause digestive discomfort on an empty stomach. Taking it with meals helps ...